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Review on the Relationship between Human Polyomaviruses-Associated Tumors and Host Immune System

Review on the Relationship between Human Polyomaviruses-Associated Tumors and Host Immune System

Authors :
Serena Delbue
Manola Comar
Pasquale Ferrante
Source :
Clinical and Developmental Immunology, Vol 2012 (2012)
Publication Year :
2012
Publisher :
Hindawi Limited, 2012.

Abstract

The polyomaviruses are small DNA viruses that can establish latency in the human host. The name polyomavirus is derived from the Greek roots poly-, which means “many,” and -oma, which means “tumours.” These viruses were originally isolated in mouse (mPyV) and in monkey (SV40). In 1971, the first human polyomaviruses BK and JC were isolated and subsequently demonstrated to be ubiquitous in the human population. To date, at least nine members of the Polyomaviridae family have been identified, some of them playing an etiological role in malignancies in immunosuppressed patients. Here, we describe the biology of human polyomaviruses, their nonmalignant and malignant potentials ability, and their relationship with the host immune response.

Details

Language :
English
ISSN :
17402522 and 17402530
Volume :
2012
Database :
Directory of Open Access Journals
Journal :
Clinical and Developmental Immunology
Publication Type :
Academic Journal
Accession number :
edsdoj.14a04a31622e4911a1eefb562265cb09
Document Type :
article
Full Text :
https://doi.org/10.1155/2012/542092