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A rare CD5-positive subgroup of diffuse large B-cell lymphoma – clinical, morphological and immunophenotypic features in Polish patients
- Source :
- Polish Journal of Pathology, Vol 67, Iss 3, Pp 235-243 (2016)
- Publication Year :
- 2016
- Publisher :
- Termedia Publishing House, 2016.
-
Abstract
- The aim of the study was to assess the incidence of CD5-positive diffuse large B-cell lymphoma (DLBCL) in the Polish population and to describe its morphologic and clinical characteristics. The study included 36 patients with CD5-positive DLBCL, diagnosed and treated in the Maria Skłodowska-Curie Institute and Oncology Centre, Warsaw, Poland and the Medical University of Warsaw, Poland in the years 2002-2013. The control group consisted of 28 patients with CD5-negative DLBCL. CD5-positive DLBCL accounted for 6.26% of all DLBCL cases diagnosed in the Maria Skłodowska-Curie Institute and Oncology Centre in the years 2008-2012. The incidence is comparable to other European countries, lower than noted in Japan and higher than in the US. Patients with CD5-positive DLBCL, in comparison to the CD5-negative group, were characterized by: (1) older age (≥ 60 vs. younger) and worse general status (ECOG ≥ 2 vs. < 2), (2) lower frequency of complete remission (CR), (3) higher expression of unfavorable prognostic factors (BCL2, FOXP1, CD44) and MMP-9, and (4) lower expression of favorable prognostic factors (CD30, cyclin D1, cyclin D3) and TIMP-2.
- Subjects :
- NHL
CD5-positive DLBCL
prognostic factors
Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 12339687 and 20849869
- Volume :
- 67
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Polish Journal of Pathology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.14d5966c0ede4e6d920bbe6e5b9b3eda
- Document Type :
- article
- Full Text :
- https://doi.org/10.5114/pjp.2016.63775