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The ubiquitination landscape of the influenza A virus polymerase

Authors :
Franziska Günl
Tim Krischuns
Julian A. Schreiber
Lea Henschel
Marius Wahrenburg
Hannes C. A. Drexler
Sebastian A. Leidel
Vlad Cojocaru
Guiscard Seebohm
Alexander Mellmann
Martin Schwemmle
Stephan Ludwig
Linda Brunotte
Source :
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

Influenza A virus replication relies on host cell-derived ubiquitination of the viral polymerase. Here, Günl et al. show that site-specific ubiquitination of PB1-K578 is acquired during infection and facilitates spatiotemporal control of polymerase dimerization and NP binding.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.155a95c62414014bbf6fda9c189f4be
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-023-36389-0