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Joint Pain and Arthritis as First Clinical Manifestation of Systemic Amyloidosis and Multiple Myeloma: Case Report and Brief Literature Review

Joint Pain and Arthritis as First Clinical Manifestation of Systemic Amyloidosis and Multiple Myeloma: Case Report and Brief Literature Review

Authors :
Francesco Mazziotta
Gabriele Buda
Maria Livia Del Giudice
Enrico Orciuolo
Edoardo Benedetti
Matilde Masini
Vincenzo De Tata
Sara Galimberti
Mario Petrini
Source :
Hematology Reports, Vol 14, Iss 1, Pp 19-23 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Amyloidosis is a rare disease that is often seen in conjunction with multiple myeloma (MM). Its damage varies depending on the anatomical site affected; however, it is believed that many cases of amyloidosis are misrecognized due to the fact that its signs and symptoms are nonspecific. Joint amyloidosis, in particular, may be confused with degenerative or autoimmune diseases. When it is associated with MM, it can significantly precede the diagnosis of the latter. We describe a case report of a woman of Nigerian heritage diagnosed with MM with widespread joint manifestations compatible with a diagnosis of amyloidosis, which had preceded the diagnosis of MM and benefited from MM treatment. Faced with the suspicion of amyloidosis, if confirmed, this can be used to anticipate the diagnosis of MM, and at a more advanced stage, it can benefit from the treatment of the MM.

Details

Language :
English
ISSN :
20388330
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Hematology Reports
Publication Type :
Academic Journal
Accession number :
edsdoj.159faeae7f8e4afea00f5857f68f7209
Document Type :
article
Full Text :
https://doi.org/10.3390/hematolrep14010004