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Prevention of Clostridium difficile infection in hamsters using a non-toxigenic strain
- Source :
- Ciência Rural, Vol 46, Iss 5, Pp 853-859 (2016)
- Publication Year :
- 2016
- Publisher :
- Universidade Federal de Santa Maria, 2016.
-
Abstract
- ABSTRACT: The present study aimed to evaluate five non-toxigenic strains of Clostridium difficile (NTCD) in vitro and to select one strain to prevent C. difficile (CDI) infection in hamsters ( Mesocricetus auratus ). The NTCD strains were evaluated for spore production in vitro, antimicrobial susceptibility and presence of antimicrobial resistance genes. Approximately 107 spores of the selected strain (Z31) were administered by esophageal gavage in hamsters pretreated with 30mg kg-1 of clindamycin. The challenge with a toxigenic strain of C. difficile was conducted at 36 and 72h, and the animals were observed for 28 days. The NTCD strain of C. difficile (Z31) was able to prevent CDI in all animals that received it.
Details
- Language :
- English, Portuguese
- ISSN :
- 16784596 and 01038478
- Volume :
- 46
- Issue :
- 5
- Database :
- Directory of Open Access Journals
- Journal :
- Ciência Rural
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.15ed90a8f7b942e988647fee0864f7b2
- Document Type :
- article
- Full Text :
- https://doi.org/10.1590/0103-8478cr20150454