All-Trans Retinoic Acid Drives Development Phase- Specific Response to Adipogenic and Myogenic Processes in Bovine Skeletal Muscle-Derived Cells

Optimal muscle and intramuscular fat development are foundational to enhanced high-quality meat production in beef cattle, involving the proliferation and differentiation of key cellular populations, such as myoblasts and preadipocytes. Vitamin A is an essential nutrient for beef cattle and plays an important role in the formation and maintenance of numerous tissue types such as adipose tissue and skeletal muscle. The objective of this study was to investigate the effect of all-trans retinoic acid (ATRA), the active form of vitamin A, on adipogenic and myogenic processes in bovine skeletal muscle-derived cells (BSMC). As a result, ATRA treatment significantly upregulated ZFP423 and MYF5 during the growth phase (P