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DETERMINATION OF ARGININE AND ASCORBIC ACID IN EFFERVESCENT TABLETS BY MULTIDIMENSIONAL CHROMATOGRAPHY
- Source :
- Drug Analytical Research, Vol 1, Iss 2 (2017)
- Publication Year :
- 2017
- Publisher :
- Universidade Federal do Rio Grande do Sul, 2017.
-
Abstract
- This paper describes a fast and direct method for quantification of arginine and ascorbic acid (vitamin C) in effervescent tablets. HPLC-UV multidimensional chromatography (RP18 and cyanopropyl columns) was developed and validated. Phosphate buffer 10 mMpH 3.4 was used as mobile phase. Satisfactory resolution between the drugs was obtained with analysis time less than 8.0 min. Method was linear in the ranges of 140-320 mg.mL-1 and 240-560 mg.mL-1 for arginine and ascorbic acid, respectively. Precision showed RSD
- Subjects :
- Biotechnology
TP248.13-248.65
Chemistry
QD1-999
Subjects
Details
- Language :
- English
- ISSN :
- 25272616
- Volume :
- 1
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Drug Analytical Research
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.16c3cf96c77453d85061811aed38abf
- Document Type :
- article