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Re-Evaluating the Transplant Glomerulopathy Lesion—Beyond Donor-Specific Antibodies
- Source :
- Transplant International, Vol 37 (2024)
- Publication Year :
- 2024
- Publisher :
- Frontiers Media S.A., 2024.
-
Abstract
- There have been significant advances in short-term outcomes in renal transplantation. However, longer-term graft survival has improved only minimally. After the first post-transplant year, it has been estimated that chronic allograft damage is responsible for 5% of graft loss per year. Transplant glomerulopathy (TG), a unique morphologic lesion, is reported to accompany progressive chronic allograft dysfunction in many cases. While not constituting a specific etiologic diagnosis, TG is primarily considered as a histologic manifestation of ongoing allo-immune damage from donor-specific anti-HLA alloantibodies (DSA). In this review article, we re-evaluate the existing literature on TG, with particular emphasis on the role of non-HLA-antibodies and complement-mediated injury, cell-mediated immune mechanisms, and early podocyte stress in the pathogenesis of Transplant Glomerulopathy.
Details
- Language :
- English
- ISSN :
- 14322277
- Volume :
- 37
- Database :
- Directory of Open Access Journals
- Journal :
- Transplant International
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.170dd07154b48b1a79583b04f4f11d9
- Document Type :
- article
- Full Text :
- https://doi.org/10.3389/ti.2024.13365