Synthesis of 2,4-disubstituted quinazolines promoted by deep eutectic solvent

An efficient deep eutectic solvent (DES) promoted reaction of 2-amino-5-chlorobenzophenone, aromatic aldehydes (benzoyl alcohols) and ammonium acetate leading to the formation of quinazolines with excellent yields is described. The use of expensive catalysts and organic solvents are avoided in this protocol with the use of DES, which is biodegradable and renewable.