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COMPARATIVE ANALYSIS OF SOLUBLE OF CD40 LIGAND LEVELS IN HEART RECIPIENTS TREATED WITH CYCLOSPORINE A AND TACROLIMUS
- Source :
- Vestnik Transplantologii i Iskusstvennyh Organov, Vol 14, Iss 2, Pp 20-24 (2012)
- Publication Year :
- 2012
- Publisher :
- Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov, 2012.
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Abstract
- Soluble form of CD40L is platelet activating factor, which is a marker of inflammation and thrombosis. Elevated levels of sCD40L before the heart transplantation are associated with the risk of early development of cardiova- scular complications. The study included 54 patients who had received heart transplants. All recipients received a triple heart immu- nosuppressive therapy, including methylprednisolone, mycophenolate mofetil and cyclosporine A (20 recipients) or methylprednisolone, mycophenolate mofetil and tacrolimus (34 recipients). Patients were not differed by age, gender, etiology of heart failure before heart transplantation (p > 0,05). In the first group of transplant recipients, the relative risk of cardiovascular events with high sCD40L levels before transplantation was 3 2 (95% CI 1,4; 12,0). In the second group of recipients, respectively, 2.69 (95% CI 1,1; 8,5). SCD40L level after heart transplan- tation was significantly higher for patients receiving cyclosporine (P < 0.05). Increasing concentrations of sCD40L are associated with a higher incidence of cardiovascular complications.
Details
- Language :
- Russian
- ISSN :
- 19951191
- Volume :
- 14
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Vestnik Transplantologii i Iskusstvennyh Organov
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.178d6f50db8f41058145ee2e91f89ae5
- Document Type :
- article
- Full Text :
- https://doi.org/10.15825/1995-1191-2012-2-20-24