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Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells

Authors :
Bhuwan Khatri
Kandice L. Tessneer
Astrid Rasmussen
Farhang Aghakhanian
Tove Ragna Reksten
Adam Adler
Ilias Alevizos
Juan-Manuel Anaya
Lara A. Aqrawi
Eva Baecklund
Johan G. Brun
Sara Magnusson Bucher
Maija-Leena Eloranta
Fiona Engelke
Helena Forsblad-d’Elia
Stuart B. Glenn
Daniel Hammenfors
Juliana Imgenberg-Kreuz
Janicke Liaaen Jensen
Svein Joar Auglænd Johnsen
Malin V. Jonsson
Marika Kvarnström
Jennifer A. Kelly
He Li
Thomas Mandl
Javier Martín
Gaétane Nocturne
Katrine Brække Norheim
Øyvind Palm
Kathrine Skarstein
Anna M. Stolarczyk
Kimberly E. Taylor
Maria Teruel
Elke Theander
Swamy Venuturupalli
Daniel J. Wallace
Kiely M. Grundahl
Kimberly S. Hefner
Lida Radfar
David M. Lewis
Donald U. Stone
C. Erick Kaufman
Michael T. Brennan
Joel M. Guthridge
Judith A. James
R. Hal Scofield
Patrick M. Gaffney
Lindsey A. Criswell
Roland Jonsson
Per Eriksson
Simon J. Bowman
Roald Omdal
Lars Rönnblom
Blake Warner
Maureen Rischmueller
Torsten Witte
A. Darise Farris
Xavier Mariette
Marta E. Alarcon-Riquelme
PRECISESADS Clinical Consortium
Caroline H. Shiboski
Sjögren’s International Collaborative Clinical Alliance (SICCA)
Marie Wahren-Herlenius
Wan-Fai Ng
UK Primary Sjögren’s Syndrome Registry
Kathy L. Sivils
Indra Adrianto
Gunnel Nordmark
Christopher J. Lessard
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

The genetic architecture underlying Sjögren’s syndrome is not fully understood. Here, the authors perform a genome-wide association study to identify 10 new genetic risk regions, implicating genes involved in immune and salivary gland function.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.17c34d06624822ae2f0ffc7f740171
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-30773-y