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Association between brachial-ankle pulse wave velocity and risk of type 2 diabetes mellitus: results from a cohort study

Authors :
Yan-mei Lou
Min-qi Liao
Chang-yi Wang
Hong-en Chen
Xiao-lin Peng
Xu-ping Gao
Shan Xu
Jian-ping Ma
Zhao Ping
Fang-fang Zeng
Source :
BMJ Open Diabetes Research & Care, Vol 8, Iss 1 (2020)
Publication Year :
2020
Publisher :
BMJ Publishing Group, 2020.

Abstract

Introduction Brachial-ankle pulse wave velocity (ba-PWV), as a simple and easily measured marker of arterial stiffness, has not been prospectively explored for its role in type 2 diabetes mellitus (T2DM) risk among the general population. This study aimed to explore the association between baseline ba-PWV value and new-onset T2DM among Chinese adults.Research design and methods Using data from Xiaotangshan Hospital, we conducted a prospective cohort study among those who underwent annual or biennial health check-up examinations and who had their ba-PWV measured from 2009 to 2016. We explored the risk of new-onset T2DM across ba-PWV tertiles using Cox proportional-hazards regression analysis.Results Of 6122 adults (68.9% male; mean age: 51.0 (SD 13.0) years) without T2DM and with ba-PWV measured at baseline, 599 participants developed T2DM during an average of 3.8 (SD 2.3) years of follow-up. After multivariable adjustment, ba-PWV was positively related to T2DM risk (p for trend=0.008). Compared with the lowest ba-PWV tertile, the HRs and their 95% CIs were 1.57 (1.18 to 2.10) for the second and 1.66 (1.24 to 2.22) for the third tertile. The risk across ba-PWV tertiles increased steadily from 1000 cm/s to 1400 cm/s and then reached a plateau. Subgroup analyses indicated a significantly higher risk among those aged

Details

Language :
English
ISSN :
20200013 and 20524897
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
BMJ Open Diabetes Research & Care
Publication Type :
Academic Journal
Accession number :
edsdoj.1825aa53e45548e1b0c349672de0c
Document Type :
article
Full Text :
https://doi.org/10.1136/bmjdrc-2020-001317