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The Role of Microsphere Structures in Bottom-Up Bone Tissue Engineering

Authors :
Ziyi Feng
Xin Su
Ting Wang
Xiaoting Sun
Huazhe Yang
Shu Guo
Source :
Pharmaceutics, Vol 15, Iss 2, p 321 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Bone defects have caused immense healthcare concerns and economic burdens throughout the world. Traditional autologous allogeneic bone grafts have many drawbacks, so the emergence of bone tissue engineering brings new hope. Bone tissue engineering is an interdisciplinary biomedical engineering method that involves scaffold materials, seed cells, and “growth factors”. However, the traditional construction approach is not flexible and is unable to adapt to the specific shape of the defect, causing the cells inside the bone to be unable to receive adequate nourishment. Therefore, a simple but effective solution using the “bottom-up” method is proposed. Microspheres are structures with diameters ranging from 1 to 1000 µm that can be used as supports for cell growth, either in the form of a scaffold or in the form of a drug delivery system. Herein, we address a variety of strategies for the production of microspheres, the classification of raw materials, and drug loading, as well as analyze new strategies for the use of microspheres in bone tissue engineering. We also consider new perspectives and possible directions for future development.

Details

Language :
English
ISSN :
19994923
Volume :
15
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Pharmaceutics
Publication Type :
Academic Journal
Accession number :
edsdoj.1850f6e3ed9146e9b619a14923de1f76
Document Type :
article
Full Text :
https://doi.org/10.3390/pharmaceutics15020321