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Ginger (Zingiber officinale Roscoe), Lemon (Citrus limon L.) Juices as Preventive Agents from Chronic Liver Damage Induced by CCl4: A Biochemical and Histological Study

Authors :
Oussama Bekkouch
Mohammed Dalli
Mohamed Harnafi
Ilham Touiss
Imane Mokhtari
Soufiane El Assri
Hicham Harnafi
Mohammed Choukri
Seok-Jae Ko
Bonglee Kim
Souliman Amrani
Source :
Antioxidants, Vol 11, Iss 2, p 390 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Zingiber officinale Roscoe and Citrus limon L. are well known for their multi-use and for their pharmacological effect in the treatment of many illnesses. This study aims to investigate the chemical composition of the ginger and lemon juice extracts and in addition, to evaluate their antioxidant properties and their hepatoprotective effect against the liver damage of Wistar rats induced by the injection of CCl4 to treated animals. The obtained effects were completed by a histological study for better confirmation of the registered pharmacological effects. The ginger juice extract was found to be rich in 4-gingerol, 6-gingediol, and 6-gingerol, while the lemon juice extract chemical composition was highlighted by the presence of eriodyctiol, rutin, hesperidin, and isorhamnetin. Concerning the antioxidant activity, the ginger, lemon juice extracts, and their formulation showed an important antioxidant potential using TAC (total antioxidant capacity), an antiradical activity against the radical DPPH• (2,2-diphenyl-1-picrylhydrazil), and a ferric reducing power. Finally, the ginger, lemon, and their formulation at different doses were able to prevent CCl4 induced liver damage. Indeed, these different bioactive compounds could be used as alternative agents for the treatment of chronic liver diseases.

Details

Language :
English
ISSN :
20763921
Volume :
11
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Antioxidants
Publication Type :
Academic Journal
Accession number :
edsdoj.187df26c476d44c8abbbbbb217a51bdb
Document Type :
article
Full Text :
https://doi.org/10.3390/antiox11020390