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Early Gastrointestinal Progression to Immunotherapy in Lung Cancer: A Report of Two Cases
Early Gastrointestinal Progression to Immunotherapy in Lung Cancer: A Report of Two Cases
- Source :
- Case Reports in Oncological Medicine, Vol 2021 (2021)
- Publication Year :
- 2021
- Publisher :
- Hindawi Limited, 2021.
-
Abstract
- Intestinal and pancreatic metastases are rare and often challenging to recognize and manage. Lung cancer patients with enteric involvement usually display poor outcomes. Hyperprogression to immunotherapy represents a concern, even though there is currently no agreement on its exact definition. Gastrointestinal hyperprogression to immune checkpoint inhibitors has not been described so far. In these cases, distinguishing disease-related symptoms from immune-related adverse events may represent a diagnostic conundrum. Here, we report two cases of non-small-cell lung cancer experiencing a rapid pancreatic and colic progression to immunotherapy, respectively. While further investigations to identify biomarkers associated with hyperprogression are warranted, clinicians should be aware of the potential unusual clinical presentations of this phenomenon.
- Subjects :
- Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Subjects
Details
- Language :
- English
- ISSN :
- 20906706 and 20906714
- Volume :
- 2021
- Database :
- Directory of Open Access Journals
- Journal :
- Case Reports in Oncological Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.188ae85d4492415098975951cac9ffac
- Document Type :
- article
- Full Text :
- https://doi.org/10.1155/2021/6692538