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Early Gastrointestinal Progression to Immunotherapy in Lung Cancer: A Report of Two Cases

Early Gastrointestinal Progression to Immunotherapy in Lung Cancer: A Report of Two Cases

Authors :
Federica Martorana
Katia Lanzafame
Giuliana Pavone
Lucia Motta
Gianmarco Motta
Nicola Inzerilli
Rosaria Carciotto
Giada Maria Vecchio
Antonino Maria Zanghì
Héctor Josè Soto Parra
Gaetano Magro
Paolo Vigneri
Source :
Case Reports in Oncological Medicine, Vol 2021 (2021)
Publication Year :
2021
Publisher :
Hindawi Limited, 2021.

Abstract

Intestinal and pancreatic metastases are rare and often challenging to recognize and manage. Lung cancer patients with enteric involvement usually display poor outcomes. Hyperprogression to immunotherapy represents a concern, even though there is currently no agreement on its exact definition. Gastrointestinal hyperprogression to immune checkpoint inhibitors has not been described so far. In these cases, distinguishing disease-related symptoms from immune-related adverse events may represent a diagnostic conundrum. Here, we report two cases of non-small-cell lung cancer experiencing a rapid pancreatic and colic progression to immunotherapy, respectively. While further investigations to identify biomarkers associated with hyperprogression are warranted, clinicians should be aware of the potential unusual clinical presentations of this phenomenon.

Details

Language :
English
ISSN :
20906706 and 20906714
Volume :
2021
Database :
Directory of Open Access Journals
Journal :
Case Reports in Oncological Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.188ae85d4492415098975951cac9ffac
Document Type :
article
Full Text :
https://doi.org/10.1155/2021/6692538