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Comparison of the oncogenomic landscape of canine and feline hemangiosarcoma shows novel parallels with human angiosarcoma

Authors :
Kim Wong
Latasha Ludwig
Oscar Krijgsman
David J. Adams
Geoffrey A. Wood
Louise van der Weyden
Source :
Disease Models & Mechanisms, Vol 14, Iss 7 (2021)
Publication Year :
2021
Publisher :
The Company of Biologists, 2021.

Abstract

Angiosarcoma (AS) is a highly aggressive tumor of blood and lymphatic vessels in humans that shares many similarities with spontaneously occurring hemangiosarcoma (HSA) in dogs and cats. To investigate the genetic suitability of HSA as a model for AS, we sequenced ∼1000 cancer genes in 41 cases of HSA and matched germline tissue: 15 canine visceral HSAs, 13 canine skin HSAs and 13 feline skin HSAs. Analysis of visceral HSAs from dogs presenting with concurrent splenic and cardiac neoplasms showed that the tumors were not independent primaries, consistent with the highly metastatic nature of HSA. Comparison of HSA to AS revealed that several driver genes were recurrently mutated in both species, such as TP53, PIK3CA, ATRX, GRIN2A and LRP1B. Similar to AS, a UV mutational signature was found in a subset of canine cutaneous HSAs and both species show differing mutational profiles between tissue sites. Our characterization of canine and feline HSA demonstrates many important parallels to AS and provides hope that future studies on these cancers will benefit of all three species.

Details

Language :
English
ISSN :
17548403 and 17548411
Volume :
14
Issue :
7
Database :
Directory of Open Access Journals
Journal :
Disease Models & Mechanisms
Publication Type :
Academic Journal
Accession number :
edsdoj.18c26fbd351f43e5a12bc018b074f0fb
Document Type :
article
Full Text :
https://doi.org/10.1242/dmm.049044