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Multimarkers approach in chest pain management in Emergency department: a focus on the prognostic role of sST2 and suPAR

Authors :
Andrea Piccioni
Silvia Baroni
Licia Antonella Scatà
Marta Scaccia
Martina Candela
Alessandra Bronzino
Francesca Sarlo
Gabriele Savioli
Marcello Candelli
Marcello Covino
Antonio Gasbarrini
Francesco Franceschi
Source :
Emergency Care Journal (2024)
Publication Year :
2024
Publisher :
PAGEPress Publications, 2024.

Abstract

Chest pain is one of the most prevalent causes of Emergency Department (ED) admission and could be a presenting symptom of Acute Coronary Syndrome (ACS). The aim of this review was to provide an overview of the research about troponin and its limitations and new biomarkers used in patients with cardiovascular diseases, with a special focus on soluble Suppression of Tumorigenicity 2 (sST2) and Soluble Urokinase Plasminogen Activator Receptor (suPAR). In January 2024, a PubMed and Reviews in Cardiovascular Medicine (RCM) search was carried out to identify all relevant papers in the past five years. 80 articles were included in the final review. ssT2 and suPAR are involved in both acute and chronic cardiovascular disease and can predict the risk of adverse events. sST2 and suPAR are promising biomarkers that, in combination with troponin, could help in the management of patients with chest pain in the ED. Further studies are needed to validate their role in management of ACS in this specific setting.

Details

Language :
English
ISSN :
22822054
Database :
Directory of Open Access Journals
Journal :
Emergency Care Journal
Publication Type :
Academic Journal
Accession number :
edsdoj.1944260f28044b190a7603d9c37ada4
Document Type :
article
Full Text :
https://doi.org/10.4081/ecj.2024.12463