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Evidence of positively selected G6PD A‐ allele reduces risk of Plasmodium falciparum infection in African population on Bioko Island

Authors :
Xue‐Yan Liang
Jiang‐Tao Chen
Yan‐Bo Ma
Hui‐Ying Huang
Dong‐De Xie
Santiago‐m Monte‐Nguba
Carlos Salas Ehapo
Urbano Monsuy Eyi
Yu‐Zhong Zheng
Xiang‐Zhi Liu
Guang‐Cai Zha
Li‐Yun Lin
Wei‐Zhong Chen
Xia Zhou
Min Lin
Source :
Molecular Genetics & Genomic Medicine, Vol 8, Iss 2, Pp n/a-n/a (2020)
Publication Year :
2020
Publisher :
Wiley, 2020.

Abstract

Abstract Background Glucose‐6‐phosphate dehydrogenase (G6PD) is an essential enzyme that protects red blood cells from oxidative damage. Although G6PD‐deficient alleles appear to confer a protective effect of malaria, the link with clinical protection against Plasmodium infection is conflicting. Methods A case–control study was conducted on Bioko Island, Equatorial Guinea and further genotyping analysis used to detect natural selection of the G6PD A‐ allele. Results Our results showed G6PD A‐ allele could significantly reduce the risk of Plasmodium falciparum infection in male individuals (adjusted odds ratio [AOR], 0.43; 95% confidence interval [CI], 0.20–0.93; p

Details

Language :
English
ISSN :
23249269
Volume :
8
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Molecular Genetics & Genomic Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.194f56bbf5544c4bbb7b0bf6deb2909
Document Type :
article
Full Text :
https://doi.org/10.1002/mgg3.1061