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An enhancer variant at 16q22.1 predisposes to hepatocellular carcinoma via regulating PRMT7 expression
- Source :
- Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
- Publication Year :
- 2022
- Publisher :
- Nature Portfolio, 2022.
-
Abstract
- The role of enhancer variants in hepatocellular carcinoma (HCC) predisposition remains unknown. Here, the authors perform a genome-wide survey of HCC-susceptible enhancer variants in 11,958 individuals, identify rs73613962 within the intronic region of PRMT7 and find that PRMT7 upregulation predisposes to HCC.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 13
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.19a98dafc1f745fb9a9e044214d5830f
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-022-28861-0