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Vitamin D supplementation lowers thrombospondin-1 levels and blood pressure in healthy adults.

Authors :
Anjalee T Amarasekera
Bahador Assadi-Khansari
Saifei Liu
Marilyn Black
Greer Dymmott
Natasha M Rogers
Aaron L Sverdlov
John D Horowitz
Doan T M Ngo
Source :
PLoS ONE, Vol 12, Iss 5, p e0174435 (2017)
Publication Year :
2017
Publisher :
Public Library of Science (PLoS), 2017.

Abstract

Vitamin D insufficiency, defined as 25-hydroxyvitamin D (25(OH)D) levels < 75nmol/L is associated with cardio-metabolic dysfunction. Vitamin D insufficiency is associated with inflammation and fibrosis, but it remains uncertain whether these anomalies are readily reversible. Therefore, we aimed to determine the effects of vitamin D supplementation on markers of: 1) nitric oxide (NO) signaling, 2) inflammation, and 3) fibrosis, in healthy volunteers with mild hypovitaminosis.Healthy volunteers (n = 35) (mean age: 45 ± 11 years) with 25(OH)D levels

Subjects

Subjects :
Medicine
Science

Details

Language :
English
ISSN :
19326203
Volume :
12
Issue :
5
Database :
Directory of Open Access Journals
Journal :
PLoS ONE
Publication Type :
Academic Journal
Accession number :
edsdoj.19ab38ebebcb4aa5af51c17f6ab9bded
Document Type :
article
Full Text :
https://doi.org/10.1371/journal.pone.0174435