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Efficient biosynthesis of nucleoside cytokinin angustmycin A containing an unusual sugar system

Authors :
Le Yu
Wenting Zhou
Yixuan She
Hongmin Ma
You-Sheng Cai
Ming Jiang
Zixin Deng
Neil P. J. Price
Wenqing Chen
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Angustmycin A is a nucleoside antibiotic having anti-mycobacterial and cytokinin activities. Here, the authors report the whole pathway leading to angustmycin A biosynthesis in Streptomyces and achieve the heterologous production of angustmycin A in E. coli.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.1a017a78f5e242bfab6c97b66db75c86
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-26928-y