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Association of right precuneus compression with apathy in idiopathic normal pressure hydrocephalus: a pilot study

Authors :
Yoshihiro Chadani
Tetsuo Kashibayashi
Takahiro Yamamoto
Atsushi Tsuda
Ryoko Fujito
Masanori Akamatsu
Naoto Kamimura
Ryuichi Takahashi
Takuji Yamagami
Hirokazu Furuya
Tetsuya Ueba
Motoaki Saito
Keiji Inoue
Hiroaki Kazui
Source :
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Abstract Apathy is frequently observed in idiopathic normal pressure hydrocephalus (iNPH) and worsens cognitive impairment and gait disturbance. In this study, we evaluated the regions associated with apathy in iNPH using statistical imaging analysis on the whole brain, both in terms of cerebral blood flow and gray matter volume. Twenty-seven patients with iNPH were assigned to two groups based on their scores on the neuropsychiatric inventory items related to apathy; 18 patients were assigned to the group with apathy (iNPH + APA) and 9 to the group without apathy (iNPH − APA). The magnetic resonance images and cerebral blood flow single-photon emission computed tomography data of the two groups were compared using statistical parametric mapping 12. The regional gray matter volume of the right precuneus was significantly larger in the iNPH + APA group than in the iNPH − APA group, but the regional cerebral blood flow in any region of the brain was not significantly different between the two groups. These results suggested that the larger gray matter volume, which is thought to reflect gray matter compression, in the precuneus might be involved in apathy in iNPH.

Subjects

Subjects :
Medicine
Science

Details

Language :
English
ISSN :
20452322
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Scientific Reports
Publication Type :
Academic Journal
Accession number :
edsdoj.1a3ce94eed9e44ac99cc7d8c7174bc3a
Document Type :
article
Full Text :
https://doi.org/10.1038/s41598-022-23800-x