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A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood

Authors :
Nuzulul Kurniansyah
Matthew O. Goodman
Tanika N. Kelly
Tali Elfassy
Kerri L. Wiggins
Joshua C. Bis
Xiuqing Guo
Walter Palmas
Kent D. Taylor
Henry J. Lin
Jeffrey Haessler
Yan Gao
Daichi Shimbo
Jennifer A. Smith
Bing Yu
Elena V. Feofanova
Roelof A. J. Smit
Zhe Wang
Shih-Jen Hwang
Simin Liu
Sylvia Wassertheil-Smoller
JoAnn E. Manson
Donald M. Lloyd-Jones
Stephen S. Rich
Ruth J. F. Loos
Susan Redline
Adolfo Correa
Charles Kooperberg
Myriam Fornage
Robert C. Kaplan
Bruce M. Psaty
Jerome I. Rotter
Donna K. Arnett
Alanna C. Morrison
Nora Franceschini
Daniel Levy
the NHLBI Trans-Omics in Precision Medicine (TOPMed) Consortium
Tamar Sofer
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Polygenic risk scores have potential to predict an individual’s risk of disease based on genetic markers. Here, the authors develop a polygenic risk score for hypertension and test it in a multi-ethnic cohort, finding that the score is associated with higher likelihood of hypertension development 4-6 years later.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.1a3f2850a7bb43a88a01df6eb8a52c37
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-31080-2