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Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF

Authors :
Jan Felix
Eaazhisai Kandiah
Steven De Munck
Yehudi Bloch
Gydo C.P. van Zundert
Kris Pauwels
Ann Dansercoer
Katka Novanska
Randy J. Read
Alexandre M.J.J. Bonvin
Bjorn Vergauwen
Kenneth Verstraete
Irina Gutsche
Savvas N. Savvides
Source :
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Publication Year :
2016
Publisher :
Nature Portfolio, 2016.

Abstract

Viruses often subvert the host immune system using molecular decoys to prevent an effective immune response. Here, the authors examine the structural details of the viral decoy receptor GIF and its antagnosim of GM-CSF and IL-2.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
7
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.1a41664ed7484e5ea4bc536b02b76f4a
Document Type :
article
Full Text :
https://doi.org/10.1038/ncomms13228