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Activation and signaling mechanism revealed by GPR119-Gs complex structures
- Source :
- Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
- Publication Year :
- 2022
- Publisher :
- Nature Portfolio, 2022.
-
Abstract
- Agonists selectively targeting GPR119 hold promise for treating metabolic disorders. Here, authors reveal that GPR119 adopts a non-canonical consensus structural scaffold with an extended ligand-binding pocket for chemically different agonists.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 13
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.1a5e75195b15441ab9ae910d66ae194b
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-022-34696-6