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The RalGAPα1–RalA signal module protects cardiac function through regulating calcium homeostasis

Authors :
Sangsang Zhu
Chao Quan
Ruizhen Wang
Derong Liang
Shu Su
Ping Rong
Kun Zhou
Xinyu Yang
Qiaoli Chen
Min Li
Qian Du
Jingzi Zhang
Lei Fang
Hong-Yu Wang
Shuai Chen
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Here the authors show that a RalGAPα1-RalA signal nexus regulates calcium homeostasis in cardiomyocytes via the calcium pump SERCA2a, which plays a protective role to maintain cardiac function under pressure overload conditions.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.1aaea80acab14b32aa57c6cf33cd0ee3
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-31992-z