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Inclusion body myositis – pathomechanism and lessons from genetics
- Source :
- Open Medicine, Vol 10, Iss 1 (2015)
- Publication Year :
- 2015
- Publisher :
- De Gruyter, 2015.
-
Abstract
- Inclusion body myositis is a rare, late-onset myopathy. Both inflammatory and myodegenerative features play an important role in their pathogenesis. Overlapping clinicopathological entities are the familial inclusion body myopathies with or without dementia. These myopathies share several clinical and pathological features with the sporadic inflammatory disease. Therefore, better understanding of the genetic basis and pathomechanism of these rare familial cases may advance our knowledge and enable more effective treatment options in sporadic IBM, which is currently considered a relentlessly progressive incurable disease.
Details
- Language :
- English
- ISSN :
- 23915463
- Volume :
- 10
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Open Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.1ae49101b9542e5ba63cdf5445fa99c
- Document Type :
- article
- Full Text :
- https://doi.org/10.1515/med-2015-0030