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17DD Yellow Fever Revaccination and Heightened Long-Term Immunity in Populations of Disease-Endemic Areas, Brazil
- Source :
- Emerging Infectious Diseases, Vol 25, Iss 8, Pp 1511-1521 (2019)
- Publication Year :
- 2019
- Publisher :
- Centers for Disease Control and Prevention, 2019.
-
Abstract
- We evaluated the duration of neutralizing antibodies and the status of 17DD vaccine–specific T- and B-cell memory following primary and revaccination regimens for yellow fever (YF) in Brazil. We observed progressive decline of plaque-reduction neutralization test (PRNT) seropositivity and of the levels of effector memory CD4+ and CD8+ T cells, as well as interferon-γ+CD8+ T cells, 10 years after primary vaccination. Revaccination restored PRNT seropositivity as well as the levels of effector memory CD4+, CD8+, and interferon-γ+CD8+ T cells. Moreover, secondary or multiple vaccinations guarantee long-term persistence of PRNT positivity and cell-mediated memory 10 years after booster vaccination. These findings support the relevance of booster doses to heighten the 17DD-YF–specific immune response to guarantee the long-term persistence of memory components. Secondary or multiple vaccinations improved the correlates of protection triggered by 17DD-YF primary vaccination, indicating that booster regimens are needed to achieve efficient immunity in areas with high risk for virus transmission.
Details
- Language :
- English
- ISSN :
- 10806040 and 10806059
- Volume :
- 25
- Issue :
- 8
- Database :
- Directory of Open Access Journals
- Journal :
- Emerging Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.1b4bf57455084e988dd27f6a3148665b
- Document Type :
- article
- Full Text :
- https://doi.org/10.3201/eid2508.181432