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Synthesis and Biological Evaluation of Novel Acenaphthene Derivatives as Potential Antitumor Agents
- Source :
- Molecules, Vol 16, Iss 3, Pp 2519-2526 (2011)
- Publication Year :
- 2011
- Publisher :
- MDPI AG, 2011.
-
Abstract
- Twelve novel acenaphthene derivatives have been synthesized. The structures of all compounds were confirmed by 1H-NMR, MS and elemental analysis. Their antitumor activities were evaluated in six human solid tumor cell lines, namely non-small cell lung cancer (H460), human colon adenocarcinoma (SW480), human breast cancer cell (MDA-MB-468 and SKRB-3), human melanoma cell (A375) and human pancreatic cancer (BxPC-3) . Among them, compound 3c shows the best antitumor activity against SKRB-3 cell line, as high as the positive control adriamycin.
- Subjects :
- synthesis
acenaphthene derivatives
antitumour activity
Organic chemistry
QD241-441
Subjects
Details
- Language :
- English
- ISSN :
- 16032519 and 14203049
- Volume :
- 16
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.1b5c5e1335c744a5979766943eaca1f1
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/molecules16032519