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Opium use and subsequent incidence of cancer: results from the Golestan Cohort Study

Authors :
Mahdi Sheikh, MD
Ramin Shakeri, PhD
Hossein Poustchi, PhD
Akram Pourshams, ProfMD
Arash Etemadi, PhD
Farhad Islami, PhD
Masoud Khoshnia, MD
Abdolsamad Gharavi, MD
Gholamreza Roshandel, PhD
Hooman Khademi, MD
Sadaf G Sepanlou, PhD
Maryam Hashemian, PhD
Abdolreza Fazel, MD
Mahdi Zahedi, MD
Behnoush Abedi-Ardekani, MD
Paolo Boffetta, ProfPhD
Sanford M Dawsey, MD
Paul D Pharoah, ProfPhD
Masoud Sotoudeh, ProfMD
Neal D Freedman, PhD
Christian C Abnet, PhD
Nicholas E Day, ProfPhD
Paul Brennan, PhD
Farin Kamangar, ProfPhD
Reza Malekzadeh, ProfMD
Source :
The Lancet Global Health, Vol 8, Iss 5, Pp e649-e660 (2020)
Publication Year :
2020
Publisher :
Elsevier, 2020.

Abstract

Summary: Background: Evidence is emerging for a role of opiates in various cancers. In this study, we aimed to investigate the association between regular opium use and cancer incidence. Methods: This study was done in a population-based cohort of 50 045 individuals aged 40–75 years from northeast Iran. Data on participant demographics, diet, lifestyle, opium use, and different exposures were collected upon enrolment using validated questionnaires. We used proportional hazards regression models to estimate hazard ratios (HRs) and corresponding 95% CIs for the association between opium use and different cancer types. Findings: During a median 10 years of follow-up, 1833 participants were diagnosed with cancer. Use of opium was associated with an increased risk of developing all cancers combined (HR 1·40, 95% CI 1·24–1·58), gastrointestinal cancers (1·31, 1·11–1·55), and respiratory cancers (2·28, 1·58–3·30) in a dose-dependent manner (ptrend

Details

Language :
English
ISSN :
2214109X
Volume :
8
Issue :
5
Database :
Directory of Open Access Journals
Journal :
The Lancet Global Health
Publication Type :
Academic Journal
Accession number :
edsdoj.1b760c4cfe8349c6925f3b1a06b6f67f
Document Type :
article
Full Text :
https://doi.org/10.1016/S2214-109X(20)30059-0