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Sudden Cardiac Death in the Young: State-of-the-Art Review in Molecular Autopsy
- Source :
- Current Issues in Molecular Biology, Vol 46, Iss 4, Pp 3313-3327 (2024)
- Publication Year :
- 2024
- Publisher :
- MDPI AG, 2024.
-
Abstract
- Sudden cardiac death (SCD) is defined as unexpected death due to a cardiac cause that occurs rapidly. Despite the identification of prevention strategies, SCD remains a serious public health problem worldwide, accounting for 15–20% of all deaths, and is therefore a challenge for modern medicine, especially when it affects young people. Sudden cardiac death in young people affects the population aged ≤ 35 years, including athletes and non-athletes, and it is due to various hereditary and non-hereditary causes. After an autopsy, if the cause remains unknown, it is called sudden unexplained death, often attributable to genetic causes. In these cases, molecular autopsy—post-mortem genetic testing—is essential to facilitate diagnostic and therapeutic pathways and/or the monitoring of family members of the cases. This review aims to elaborate on cardiac disorders marked by genetic mutations, necessitating the post-mortem genetic investigation of the deceased for an accurate diagnosis in order to facilitate informed genetic counseling and to implement preventive strategies for family members of the cases.
Details
- Language :
- English
- ISSN :
- 14673045 and 14673037
- Volume :
- 46
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Current Issues in Molecular Biology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.1be0d5cbe10840b496379e94401fd3af
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/cimb46040207