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Sudden Cardiac Death in the Young: State-of-the-Art Review in Molecular Autopsy

Authors :
Cecilia Salzillo
Vincenza Sansone
Francesco Napolitano
Source :
Current Issues in Molecular Biology, Vol 46, Iss 4, Pp 3313-3327 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Sudden cardiac death (SCD) is defined as unexpected death due to a cardiac cause that occurs rapidly. Despite the identification of prevention strategies, SCD remains a serious public health problem worldwide, accounting for 15–20% of all deaths, and is therefore a challenge for modern medicine, especially when it affects young people. Sudden cardiac death in young people affects the population aged ≤ 35 years, including athletes and non-athletes, and it is due to various hereditary and non-hereditary causes. After an autopsy, if the cause remains unknown, it is called sudden unexplained death, often attributable to genetic causes. In these cases, molecular autopsy—post-mortem genetic testing—is essential to facilitate diagnostic and therapeutic pathways and/or the monitoring of family members of the cases. This review aims to elaborate on cardiac disorders marked by genetic mutations, necessitating the post-mortem genetic investigation of the deceased for an accurate diagnosis in order to facilitate informed genetic counseling and to implement preventive strategies for family members of the cases.

Details

Language :
English
ISSN :
14673045 and 14673037
Volume :
46
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Current Issues in Molecular Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.1be0d5cbe10840b496379e94401fd3af
Document Type :
article
Full Text :
https://doi.org/10.3390/cimb46040207