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CHARACTERIZATION OF SIGNAL CONDUCTION ALONG DEMYELINATED AXONS BY ACTION-POTENTIAL-ENCODED SECOND HARMONIC GENERATION

Authors :
ZHI-HUI LUO
JIANG-XU CHEN
YI-MEI HUANG
HONG-QIN YANG
JU-QIANG LIN
HUI LI
SHU-SEN XIE
Source :
Journal of Innovative Optical Health Sciences, Vol 7, Iss 1, Pp 1330003-1-1330003-9 (2014)
Publication Year :
2014
Publisher :
World Scientific Publishing, 2014.

Abstract

Action-potential-encoded optical second harmonic generation (SHG) has been recently proposed for use in detecting the axonal damage in patients with demyelinating diseases. In this study, the characterization of signal conduction along axons of two different levels of demyelination was studied via a modified Hodgkin–Huxley model, because some types of demyelinating disease, i.e., primary progressive and secondary progressive multiple sclerosis, are difficult to be distinguished by magnetic resonance imaging (MRI), we focused on the differences in signal conduction between two different demyelinated axons, such as the first-level demyelination and the second-level demyelination. The spatio-temporal distribution of action potentials along demyelinated axons and conduction properties including the refractory period and frequency encoding in these two patterns were investigated. The results showed that demyelination could induce the decrease both in the amplitude of action potentials and the ability of frequency coding. Furthermore, the signal conduction velocity in the second-level demyelination was about 21% slower than that in the first-level demyelination. The refractory period in the second-level demyelination was about 32% longer than the first-level. Thus, detecting the signal conduction in demyelinated axons by action-potential-encoded optical SHG could greatly improve the assessment of demyelinating disorders to classify the patients. This technique also offers a potential fast and noninvasive optical approach for monitoring membrane potential.

Details

Language :
English
ISSN :
17935458 and 17937205
Volume :
7
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Journal of Innovative Optical Health Sciences
Publication Type :
Academic Journal
Accession number :
edsdoj.1be2667000b4134a0d0dea9a25b0c71
Document Type :
article
Full Text :
https://doi.org/10.1142/S1793545813300036