Sex-biased and parental allele-specific gene regulation by KDM6A

Highlights The majority of KDM6A targets are regulated from one allele or the other with allelic downregulation showing a maternal allele bias. Kdm6a knockout affects genes that have been implicated in phenotypes of Kabuki syndrome caused by KDM6A mutations in human. KDM6A facilitates sex-biased gene expression, particularly female-biased expression.