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Correlation between modifiable risk factors and age-related macular degeneration: A Case–control study

Correlation between modifiable risk factors and age-related macular degeneration: A Case–control study

Authors :
Dhaval Patel
Harsha Bhattacharjee
Saloni Shah
Krati Gupta
Rupal Chaudhari
Kamla Sadia
Saurabh Deshmukh
Source :
TNOA Journal of Ophthalmic Science and Research, Vol 56, Iss 3, Pp 163-166 (2018)
Publication Year :
2018
Publisher :
Wolters Kluwer Medknow Publications, 2018.

Abstract

Aim: The aim of the study is to find the correlation between modifiable risk factors such as body mass index (BMI), waist circumference (WC), and smoking with age-related macular degeneration (AMD). Materials and Methods: In this hospital-based, observational, case-control study, 100 patients presenting to our outpatient department over a period of 1 year were included in the study. The selected participants were grouped into the AMD group which included 50 eyes with nonneovascular AMD and neovascular AMD along with 50 eyes as a control group. All participants underwent comprehensive ophthalmological examination along with measurement of weight, height, and WC. Results: Fifty eyes of 50 patients diagnosed to have AMD and 50 eyes of 50 age-matched controls were included in this study. The mean age was 66 years (49–85 years). The mean BMI in patients with neovascular AMD was 27.74 kg/m2 ± 4.93 (n = 19). The mean BMI in patients with nonneovascular AMD was 25.58 kg/m2 ± 2.90 (n = 31), whereas mean BMI in the control group was 23.85 kg/m2 ± 3.31 (n = 50). There was a statistically significant difference between the two AMD groups and the control group with respect to BMI (ANOVA; F = 8.605; DF = 2; P < 0.001). The mean WC in patients with neovascular AMD was 104.63 cm ± 5.78 (n = 19). The mean WC in patients with nonneovascular AMD was 102.6 cm ± 6.1 (n = 31), whereas mean WC in the control group was 91.7 cm ± 6.7 (n = 50), and the difference was statistically significant (ANOVA; F = 42.70; DF = 2; P < 0.001). Statistically significant difference was observed between the smokers belonging to case and control groups (ANOVA; F = 13.967; DF = 2; P < 0.001). Conclusion: A statistically significant correlation exists between BMI, WC, smoking, and the severity of AMD.

Details

Language :
English
ISSN :
25894528 and 25894536
Volume :
56
Issue :
3
Database :
Directory of Open Access Journals
Journal :
TNOA Journal of Ophthalmic Science and Research
Publication Type :
Academic Journal
Accession number :
edsdoj.1d168cf7614f43d2994b690a81e844ae
Document Type :
article
Full Text :
https://doi.org/10.4103/tjosr.tjosr_79_18