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Strategies for the synthesis and molecular modeling aiming to discover biorational agricultural insecticides

Authors :
Rejane G. D. Khodyuk
DĂȘnis P. de Lima
Adilson Beatriz
Marcos S. do Amaral
Edson dos A. dos Santos
Paulo C. Prado
Source :
Orbital: The Electronic Journal of Chemistry, Vol 4, Iss 1, Pp 47-48 (2012)
Publication Year :
2012
Publisher :
Universidade Federal de Mato Grosso do Sul, 2012.

Abstract

This work presents two proposals for the synthesis of halogenated aryl thiosulfonates which are of biologically interesting compounds. Inhibitors of proteases and juvenile hormone mimetizing are already successfully employed for managing pest-insects However, many of these products can be always improved in the aspects of specificity implying in low cost to the farmer. The major objective of this work is the synthesis of thiosulfonates analogues of commercial products which are inhibitors of serine-protease and juvenile hormone mimetizing compounds that can be applied as leads for production of insecticides that can contribute to the control of pest-insects in economically important plantation and stored grains. The scientific research group SINTMOLB (CNPq) is involved with studies related to the synthesis of phenolic compounds with insecticidal potential. Some important results have already been obtained and, in this new project, it is being explored the synthesis of new compounds, computational analysis, and biological tests to evaluate protease inhibitory effect.

Details

Language :
English
ISSN :
19846428
Volume :
4
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Orbital: The Electronic Journal of Chemistry
Publication Type :
Academic Journal
Accession number :
edsdoj.1d4459e4704bc394fafc4c90ba52a8
Document Type :
article
Full Text :
https://doi.org/10.17807/orbital.v4i1.361