A new perspective on bone development in vitamin D deficiency-associated obese children

Abstract Vitamin D is crucial for maintaining bone health and development, and bone mineral accumulation during childhood and adolescence affects long-term bone health. Vitamin D deficiency has been widely recognized as one of the main causes of osteoporosis and fractures, especially during the growth and development stage of children. Recent studies have shown that vitamin D deficiency may affect the deviation of bone development in children by mediating lipid metabolism disorders, but its specific mechanism of action has not been fully elucidated. In this study, through clinical correlation analysis, it was found that vitamin D deficiency was negatively correlated with lipid metabolism levels. Subsequently, lipidomic analysis of vitamin D-deficient mice and children showed that triglycerides were the main lipid metabolites. It was found that the triglyceride synthesis pathway plays a key role in bone development in vitamin D-deficient obese children. Our study found that vitamin D deficiency mediates bone dysplasia by affecting triglyceride synthesis. These findings provide new insights into the mechanisms by which vitamin D deficiency affects bone development in children, which may guide more precise clinical interventions and support the development of new clinical treatments.