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Asynchronous release sites align with NMDA receptors in mouse hippocampal synapses

Authors :
Shuo Li
Sumana Raychaudhuri
Stephen Alexander Lee
Marisa M. Brockmann
Jing Wang
Grant Kusick
Christine Prater
Sarah Syed
Hanieh Falahati
Raul Ramos
Tomas M. Bartol
Eric Hosy
Shigeki Watanabe
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Action potentials induce synchronous and asynchronous release of neurotransmitters. Here, the authors show that the synchronous and asynchronous release sites are aligned with AMPARs and NMDARs, respectively, in mouse hippocampal synapses. This organization allows efficient activation of NMDARs.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.1dbfabc834db792c456f47bdb3077
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-21004-x