Effect of insulin resistance on gonadotropin and bone mineral density in nondiabetic postmenopausal women

ObjectiveThe effects of insulin resistance (IR) on bone mineral density (BMD) are unclear. This investigation aimed to assess the impact of IR and hyperinsulinemia on bone health. Determine whether IR mediates the link between follicle-stimulating hormone (FSH) and bone mass in nondiabetic postmenopausal women.DesignRetrospective cross-sectional study.SettingHealth checkup center of Hangzhou Women’s Hospital.MethodsThis study comprised 437 nondiabetic postmenopausal women. BMD was evaluated using dual-energy X-rays. Fasting sera were analyzed for insulin and glucose levels, and indicators related to IR were determined. By pathway analysis, we examined the indirect effects of FSH on BMD via the mediators Homeostatic Model Assessment for insulin resistance (HOMA-IR) and fasting insulin (FINS) after correction for confounding factors.ResultAfter adjusting for age and body mass index (BMI) in linear regression, HOMA-IR and FINS were linked with FSH (P