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Comparison of the hyper-cvad with an institutional regimen for the treatment of acute lymphoblastic leukemia in adults in a hospital of Mexico
- Source :
- Revista Peruana de Medicina Experimental y Salud Pública, Vol 31, Iss 3 (2014)
- Publication Year :
- 2014
- Publisher :
- Instituto Nacional de Salud, 2014.
-
Abstract
- In order to assess the mortality and toxicity of the Hyper-CVAD protocol used as first-line treatment of acute lymphoblastic leukemia, a retrospective cohort study was performed in patients less than 40 years of age from March to September 2011 treated with Hyper-CVAD regimen. Mortality and toxicity was compared with the results of patients treated with the institutional HGMLAL07 regimen between 2009-2012. 18 patients were included; the median age was 26 years old. Complete remissions (67.7% versus 81.9%) as well as one-year (40% versus 62%) and 2 year survival rates (18% versus 34%) were lower with the Hyper-CVAD regimen. By selecting only patients younger than 35 years, the effectiveness of Hyper-CVAD was also lower. In our experience and because of its high cost and toxicity, the Hyper-CVAD regimen should be limited to patients with relapsed or refractory leukemia.
Details
- Language :
- Spanish; Castilian
- ISSN :
- 17264634 and 17264642
- Volume :
- 31
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Revista Peruana de Medicina Experimental y Salud Pública
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.1eb20b3f48b84896a191ab030b7ef6e3
- Document Type :
- article
- Full Text :
- https://doi.org/10.17843/rpmesp.2014.313.91