Back to Search Start Over

Food intake regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta

Authors :
Cepeda Libia A
Garcés Maria F
González C Ruth
Bravo Susana B
Caminos Jorge E
González Adriana C
Cordido Fernando
López Miguel
Diéguez Carlos
Source :
Reproductive Biology and Endocrinology, Vol 6, Iss 1, p 14 (2008)
Publication Year :
2008
Publisher :
BMC, 2008.

Abstract

Abstract Background Neuropeptide Y (NPY), agouti related peptide (AgRP), cocaine and amphetamine-regulated transcript (CART) and melanocortins, the products of the proopiomelanocortin (POMC), are hypothalamic peptides involved in feeding regulation and energy homeostasis. Recent evidence has demonstrated their expression in rat and human placenta. Methods In the current study, we have investigated the expression of those neuropeptides in the rat placenta by real-time PCR using a model of maternal food restriction. Results Our results showed that placental-derived neuropeptides were regulated through pregnancy and following food restriction. Conclusion These data could indicate that placental-derived neuropeptides represent a local regulatory circuit that may fine-tune control of energy balance during pregnancy.

Details

Language :
English
ISSN :
14777827
Volume :
6
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Reproductive Biology and Endocrinology
Publication Type :
Academic Journal
Accession number :
edsdoj.1ed1db9735f44121b7f406727742db88
Document Type :
article
Full Text :
https://doi.org/10.1186/1477-7827-6-14