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The Effect of L-Ascorbic Acid-2-Phosphate Magnesium on Chicks Injected a Radical Initiator

Authors :
Keisuke Sasaki
Mitsuaki Sano
Jun-ichi Satoh
Yukou Ohishi
Shinobu Itoh
Tetsuro Nakaya
Yosuke Aoyagi
Source :
The Journal of Poultry Science, Vol 39, Iss 3, Pp 179-184 (2002)
Publication Year :
2002
Publisher :
Japan Poultry Science Association, 2002.

Abstract

Effect of L-ascorbic acid phosphate magnesium (APM) on chicks injected radical initiator, 2, 2′-azobis(2-amidinopropane) dihydrochloride (AAPH), was examined. Chicks were fed APM as ascorbate resource for 7 days. Birds were administrated AAPH by intraperitoneal injection after APM feeding. The changes of ascorbate and thiobarbituric acid reactive substances (TBARS) in plasma and liver were determined before, and 3 and 6 hours after AAPH injection. Both plasma and liver ascorbate increased by APM feeding. After AAPH injection, liver ascorbate decreased, but plasma ascorbate increased in both control and APM-fed birds. AAPH administration raised liver TBARS, but decreased plasma TBARS. Both plasma and liver TBARS were lower in APM group than control group before and after AAPH administration. Peroxyl radical trapping activity in plasma was elevated by APM feeding as compared to control group. APM was utilized as ascorbate, and was effective for prevention of oxidative stresses derived from AAPH by increasing plasma and liver ascorbate and plasma radical trapping activity.

Details

Language :
English
ISSN :
13467395 and 13490486
Volume :
39
Issue :
3
Database :
Directory of Open Access Journals
Journal :
The Journal of Poultry Science
Publication Type :
Academic Journal
Accession number :
edsdoj.1f130b812a844d2d9b04952bd9fa27cf
Document Type :
article
Full Text :
https://doi.org/10.2141/jpsa.39.179