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Enzyme-catalyzed C–F bond formation and cleavage
- Source :
- Bioresources and Bioprocessing, Vol 6, Iss 1, Pp 1-8 (2019)
- Publication Year :
- 2019
- Publisher :
- SpringerOpen, 2019.
-
Abstract
- Abstract Organofluorines are widely used in a variety of applications, ranging from pharmaceuticals to pesticides and advanced materials. The widespread use of organofluorines also leads to its accumulation in the environment, and two major questions arise: how to synthesize and how to degrade this type of compound effectively? In contrast to a considerable number of easy-access chemical methods, milder and more effective enzymatic methods remain to be developed. In this review, we present recent progress on enzyme-catalyzed C–F bond formation and cleavage, focused on describing C–F bond formation enabled by fluorinase and C–F bond cleavage catalyzed by oxidase, reductase, deaminase, and dehalogenase.
Details
- Language :
- English
- ISSN :
- 21974365
- Volume :
- 6
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Bioresources and Bioprocessing
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.1f4f262a255a40b8afe305234e38f909
- Document Type :
- article
- Full Text :
- https://doi.org/10.1186/s40643-019-0280-6