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Association between Maternal Non-Coding Interferon-λ Polymorphisms and Congenital Zika Syndrome in a Cohort from Brazilian Northeast

Authors :
Átila Duque Rossi
Fabio Rueda Faucz
Adriana Melo
Girlene Souza de Azevedo
Paula Pezzuto
Ohanna Cavalcanti de Lima Bezerra
Fernanda Saloum de Neves Manta
Tamiris Azamor
Bruno Luiz Fonseca Schamber-Reis
Amilcar Tanuri
Milton Ozório Moraes
Renato Santana Aguiar
Constantine A. Stratakis
Cynthia Chester Cardoso
Source :
Viruses, Vol 13, Iss 11, p 2253 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Congenital Zika syndrome (CZS) is characterized by a diverse group of congenital malformations induced by ZIKV infection during pregnancy. Type III interferons have been associated with placental immunity against ZIKV and restriction of vertical transmission in mice, and non-coding single-nucleotide polymorphisms (SNPs) on these genes are well known to influence susceptibility to other viral infections. However, their effect on ZIKV pathogenesis has not yet been explored. To investigate whether maternal non-coding SNPs at IFNL genes are associated with CZS, 52 women infected with ZIKV during pregnancy were enrolled in a case–control association study. A total of 28 women were classified as cases and 24 as controls based on the presence or absence of CZS in their infants, and seven Interferon-λ non-coding SNPs (rs12980275, rs8099917, rs4803217, rs4803219, rs8119886, rs368234815, rs12979860) were genotyped. The results of logistic regression analyses show an association between the G allele at rs8099917 and increased susceptibility to CZS under a log-additive model (adjustedOR = 2.80; 95%CI = 1.14–6.91; p = 0.02), after adjustment for trimester of infection and genetic ancestry. These results provide evidence of an association between Interferon-λ SNPs and CZS, suggesting rs8099917 as a promising candidate for further studies on larger cohorts.

Details

Language :
English
ISSN :
19994915
Volume :
13
Issue :
11
Database :
Directory of Open Access Journals
Journal :
Viruses
Publication Type :
Academic Journal
Accession number :
edsdoj.1fbefc8d57cb4b1ca2c49d02652c14c5
Document Type :
article
Full Text :
https://doi.org/10.3390/v13112253