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Neutrophil extracellular traps in the cross-talk between periodontitis and chronic kidney disease

Authors :
Shucheng Hu
Ruhan Yang
Wenying Yang
Jiaqi Tang
Weijun Yu
Dan Zhao
Lu Lin
Yuting Gu
Min Jin
Ziyuan Xu
Qin Wang
Eryi Lu
Source :
BMC Oral Health, Vol 24, Iss 1, Pp 1-10 (2024)
Publication Year :
2024
Publisher :
BMC, 2024.

Abstract

Abstract Background The objective was to evaluate the level of neutrophil extracellular traps (NETs) in patients with chronic kidney disease (CKD) and periodontitis, and to explore the relationship between NETs and both diseases. Methods 63 CKD and 40 non-CKD participants were recruited and underwent periodontal examination, among which 35 early CKD patients underwent periodontal therapy. The concentrations of NETs were determined by dsDNA assay in gingival crevicular fluid (GCF) and plasma, and by flow cytometry or immunofluorescence assay in blood and gingival tissues. The correlations between NETs and clinical parameters were analyzed. The influence of periodontal therapy on periodontitis, CKD and NETs concentrations was also evaluated. Results CKD patients had higher concentrations of NETs in plasma than non-CKD patients, and NETs concentrations were also increased in both GCF and plasma of patients with periodontitis than that of periodontally healthy patients. NETs concentrations were positively correlated with increased clinical parameters of CKD and periodontitis. The positive correlation between CKD and periodontitis was demonstrated. Moreover, periodontal therapy ameliorated periodontitis and CKD, and reduced NETs concentrations in GCF of patients. Conclusions This study revealed that NETs might be a possible bridge between periodontitis and CKD, and suggested the potential target for therapy.

Details

Language :
English
ISSN :
14726831
Volume :
24
Issue :
1
Database :
Directory of Open Access Journals
Journal :
BMC Oral Health
Publication Type :
Academic Journal
Accession number :
edsdoj.1ffff67ede9a45f883addfb7ed8f39ba
Document Type :
article
Full Text :
https://doi.org/10.1186/s12903-024-05071-2