Back to Search Start Over

Reduction of primary graft dysfunction using cytokine adsorption during organ preservation and after lung transplantation

Authors :
Haider Ghaidan
Martin Stenlo
Anna Niroomand
Margareta Mittendorfer
Gabriel Hirdman
Nika Gvazava
Dag Edström
Iran A. N. Silva
Ellen Broberg
Oskar Hallgren
Franziska Olm
Darcy E. Wagner
Leif Pierre
Snejana Hyllén
Sandra Lindstedt
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Lung transplantation is hindered by the scarcity of organs and by mortality following primary graft dysfunction. Here, the authors show that cytokine absorption can be used in donor lungs during ex vivo lung perfusion and post-transplant, and leads to restored lung function and reduced primary graft dysfunction in animal models.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.20017d7c15344f61abdebc6096d8a45e
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-31811-5