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Pilot study of Tremelimumab with and without cryoablation in patients with metastatic renal cell carcinoma

Authors :
Matthew T. Campbell
Surena F. Matin
Alda L. Tam
Rahul A. Sheth
Kamran Ahrar
Rebecca S. Tidwell
Priya Rao
Jose A. Karam
Christopher G. Wood
Nizar M. Tannir
Eric Jonasch
Jianjun Gao
Amado J. Zurita
Amishi Y. Shah
Sonali Jindal
Fei Duan
Sreyashi Basu
Hong Chen
Alexsandra B. Espejo
James P. Allison
Shalini S. Yadav
Padmanee Sharma
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Anti-CTLA4 therapy has not been comprehensively explored for the treatment of metastatic renal cell carcinoma (mRCC). Here, in a pilot study of anti-CTLA4 therapy with or without cryoablation in mRCC, the authors report that the combination is feasible and enhances immune infiltration in patients with metastatic clear cell histology.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.204efb116032411484ebc80c52f409dc
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-26415-4