Triglyceride glucose index, its modified indices, and triglyceride HDL-C ratio as predictor markers of insulin resistance in prediabetic individuals

Background: Prediabetes is a strong hazard for developing of both cardiovascular disorders and diabetes mellitus. Insulin resistant predisposes to prediabetes and type 2 diabetes mellitus that all are strongly correlated with development of cardiovascular disorders. Recently, the triglyceride glucose index, its modified indices and the ratio of triglyceride/ high density lipoprotein-cholesterol have been suggested as sensible surrogate markers of insulin resistant. Objectives: The current study aimed to evaluate the triglyceride glucose index, its modified indices and triglyceride/ high density lipoprotein-cholesterol ratio among individuals with prediabetes compared to healthy control. Materials and Methods: This study was carried out as a case control among 120 participants, 60 prediabetic individuals and 60 apparently healthy individuals as a control group. Prediabetic individuals were obtained from relatives of patients with diabetes mellitus visiting Endocrinology Unit at Azadi Teaching Hospital and 60 healthy individuals were chosen from medical staffs of Azadi Teaching Hospital. Results: There were statistically significant higher mean level of indices in individuals with prediabetes with exception of triglyceride/ high density lipoprotein-cholesterol ratio that was insignificantly higher. There was a significant positive correlation of abnormal homeostatic model assessment of insulin resistance with triglyceride/ high density lipoprotein-cholesterol ratio (r = 0.651), and triglyceride glucose index (r = 0.390) whereas insignificant positive correlation with its modified index. Conclusion: The mean level and prevalence of abnormal TyG index, TyG-BMI and TyG-WC were significantly higher in prediabetic individuals, whereas, TG/HDL-c was insignificantly higher compared to control individuals.