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Genetically Related Avian Influenza H7N9 Viruses Exhibit Different Pathogenicity in Mice
- Source :
- Animals, Vol 13, Iss 23, p 3680 (2023)
- Publication Year :
- 2023
- Publisher :
- MDPI AG, 2023.
-
Abstract
- Avian influenza viruses can cross species barriers and adapt to mammals. The H7N9 subtype AIV that emerged in China in 2013 caused 1568 human infections, with a mortality rate of nearly 40%. We conducted a retrospective analysis of H7N9 viruses that were isolated in live poultry markets in 2013. We found that two avian-origin H7N9 isolates, A/chicken/Eastern China/JTC4/2013 and A/chicken/Eastern China/JTC11/2013, have a similar genetic background but exhibit different pathogenicity in mice. Whole-genome alignment of the two H7N9 viruses was carried out, and only six amino acid differences mapped in five genes, including the well-known virulence molecular marker PB2-E627K. Our retrospective analysis highlighted the importance of monitoring the adaptive mutations in avian influenza viruses with zoonotic potential.
- Subjects :
- H7N9
pathogenicity
PB2-E627K
mice
Veterinary medicine
SF600-1100
Zoology
QL1-991
Subjects
Details
- Language :
- English
- ISSN :
- 20762615
- Volume :
- 13
- Issue :
- 23
- Database :
- Directory of Open Access Journals
- Journal :
- Animals
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.20eb902985ac49ffa7c0f5cc8bcf0e03
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/ani13233680