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Metabolic Control of γδ T Cell Function
Metabolic Control of γδ T Cell Function
- Source :
- Infectious Microbes & Diseases, Vol 3, Iss 3, Pp 142-148 (2021)
- Publication Year :
- 2021
- Publisher :
- Wolters Kluwer Health, 2021.
-
Abstract
- Abstract. Metabolic change is associated with cell activities, such as signal transduction, cell differentiation, and cell cycle. In the pathogenesis of autoimmune diseases, abnormal activation of T cells is often accompanied by changes in their metabolism. Conversely, the changes of metabolites can also regulate the proliferation, differentiation, and function of T cells. As a bridge between innate and adaptive immune responses, γδ T cells have unique biological characteristics and functions. However, the immunometabolic mechanism of γδ T cells has been a novel field for research in recent years. In this review, we summarize the influence of metabolic pathways and nutrients on γδ T cell function, and metabolic features of γδ T cell subsets, which may provide new insights in interventions targeting γδ T cells in disease control.
- Subjects :
- Infectious and parasitic diseases
RC109-216
Subjects
Details
- Language :
- English
- ISSN :
- 26415917 and 00000000
- Volume :
- 3
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Infectious Microbes & Diseases
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.20f4f2d44721a85ed497601b6f4f
- Document Type :
- article
- Full Text :
- https://doi.org/10.1097/IM9.0000000000000054