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Metabolic Control of γδ T Cell Function

Metabolic Control of γδ T Cell Function

Authors :
Ziyu Meng
Guangchao Cao
Quanli Yang
Hengwen Yang
Jianlei Hao
Zhinan Yin
Fudi Wang
Source :
Infectious Microbes & Diseases, Vol 3, Iss 3, Pp 142-148 (2021)
Publication Year :
2021
Publisher :
Wolters Kluwer Health, 2021.

Abstract

Abstract. Metabolic change is associated with cell activities, such as signal transduction, cell differentiation, and cell cycle. In the pathogenesis of autoimmune diseases, abnormal activation of T cells is often accompanied by changes in their metabolism. Conversely, the changes of metabolites can also regulate the proliferation, differentiation, and function of T cells. As a bridge between innate and adaptive immune responses, γδ T cells have unique biological characteristics and functions. However, the immunometabolic mechanism of γδ T cells has been a novel field for research in recent years. In this review, we summarize the influence of metabolic pathways and nutrients on γδ T cell function, and metabolic features of γδ T cell subsets, which may provide new insights in interventions targeting γδ T cells in disease control.

Details

Language :
English
ISSN :
26415917 and 00000000
Volume :
3
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Infectious Microbes & Diseases
Publication Type :
Academic Journal
Accession number :
edsdoj.20f4f2d44721a85ed497601b6f4f
Document Type :
article
Full Text :
https://doi.org/10.1097/IM9.0000000000000054