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The Synthesis of a Pyrazol Analogon of Porphobilinogen with the Help of the Mukaiyama Aldol Reaction

Authors :
André Chaperon
Hugo Bertschy
Anne-Laurence Franz-Schrumpf
Bertrand Hugelet
Antonia Neels
Helen Stoeckli-Evans
Reinhard Neier
Source :
CHIMIA, Vol 57, Iss 10 (2003)
Publication Year :
2003
Publisher :
Swiss Chemical Society, 2003.

Abstract

The synthesis of a pyrazol analogon of porphobilinogen is described. The Mukaiyama crossed aldol reaction is the key step of our approach. The retrosynthetic analysis follows the mechanism for the biosynthesis of porphobilinogen initially proposed by Shemin.

Details

Language :
German, English, French
ISSN :
00094293 and 26732424
Volume :
57
Issue :
10
Database :
Directory of Open Access Journals
Journal :
CHIMIA
Publication Type :
Academic Journal
Accession number :
edsdoj.210b88743ecc4e298789ab5b04983ec1
Document Type :
article
Full Text :
https://doi.org/10.2533/000942903777678812